21  Technical Sections To Write

to do!

• Explain basic Clinical Trial Simulation (Simulation/Estimation * 1000)

• Explain key concepts around how we define/assess precision of DR

• Explain key concepts around how we define/assess bias of DR

• More advanced topics for optimal designs of DR, like D-optimality and V-optimality

• Compare optimal(adaptive) designs of D-E-R versus DR

• Introduce Planned Titration trials (a much better name for “forced” titration!)

• Explain the value of ER models for prediction (extrapolation to new regimens, pediatrics etc.)

• Explain the benefit of dose titration with respect to tolerance

• Have sections entitled:

  • Design and Analysis of Population D-E-R Trials

  • Design and Analysis of Individual D-E-R Trials

• Introduce technical code to fit D-E-R models? e.g. Bayesian analysis using HMC in STAN? Mention diffuse priors (better in Appendix?)

• Show case examples where drugs are individualised (to remove the mystery!)